Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation

Centrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the incidence, consequence and origins of this abnormality are poorly understood. Here, we screened the NCI-60 panel of hum...

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Publicado no:Nat Commun
Main Authors: Marteil, Gaëlle, Guerrero, Adan, Vieira, André F., de Almeida, Bernardo P., Machado, Pedro, Mendonça, Susana, Mesquita, Marta, Villarreal, Beth, Fonseca, Irina, Francia, Maria E., Dores, Katharina, Martins, Nuno P., Jana, Swadhin C., Tranfield, Erin M., Barbosa-Morais, Nuno L., Paredes, Joana, Pellman, David, Godinho, Susana A., Bettencourt-Dias, Mónica
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2018
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871873/
https://ncbi.nlm.nih.gov/pubmed/29593297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03641-x
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