Over-elongation of centrioles in cancer promotes centriole amplification and chromosome missegregation

Centrosomes are the major microtubule organising centres of animal cells. Deregulation in their number occurs in cancer and was shown to trigger tumorigenesis in mice. However, the incidence, consequence and origins of this abnormality are poorly understood. Here, we screened the NCI-60 panel of hum...

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Bibliografiset tiedot
Julkaisussa:Nat Commun
Päätekijät: Marteil, Gaëlle, Guerrero, Adan, Vieira, André F., de Almeida, Bernardo P., Machado, Pedro, Mendonça, Susana, Mesquita, Marta, Villarreal, Beth, Fonseca, Irina, Francia, Maria E., Dores, Katharina, Martins, Nuno P., Jana, Swadhin C., Tranfield, Erin M., Barbosa-Morais, Nuno L., Paredes, Joana, Pellman, David, Godinho, Susana A., Bettencourt-Dias, Mónica
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2018
Aiheet:
Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5871873/
https://ncbi.nlm.nih.gov/pubmed/29593297
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-018-03641-x
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