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α4βδ GABA(A) receptors trigger synaptic pruning and reduce dendritic length of female mouse CA3 hippocampal pyramidal cells at puberty

Synaptic pruning during adolescence is critical for optimal cognition. The CA3 hippocampus contains unique spine types and plays a pivotal role in pattern separation and seizure generation, where sex differences exist, but adolescent pruning has only been studied in the male. Thus, for the present s...

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Vydáno v:Neuroscience
Hlavní autoři: Parato, Julie, Shen, Hui, Smith, Sheryl S.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2018
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6411036/
https://ncbi.nlm.nih.gov/pubmed/30496825
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2018.11.032
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