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Synaptic pruning in the female hippocampus is triggered at puberty by extrasynaptic GABA(A) receptors on dendritic spines

Adolescent synaptic pruning is thought to enable optimal cognition because it is disrupted in certain neuropathologies, yet the initiator of this process is unknown. One factor not yet considered is the α4βδ GABA(A) receptor (GABAR), an extrasynaptic inhibitory receptor which first emerges on dendri...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Afroz, Sonia, Parato, Julie, Shen, Hui, Smith, Sheryl Sue
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4871702/
https://ncbi.nlm.nih.gov/pubmed/27136678
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.15106
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