Pluripotent stem cell-derived myogenic progenitors remodel their molecular signature upon in vivo engraftment

Optimal cell-based therapies for the treatment of muscle degenerative disorders should not only regenerate fibers but provide a quiescent satellite cell pool ensuring long-term maintenance and regeneration. Conditional expression of Pax3/Pax7 in differentiating pluripotent stem cells (PSCs) allows t...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Incitti, Tania, Magli, Alessandro, Darabi, Radbod, Yuan, Ce, Lin, Karena, Arpke, Robert W., Azzag, Karim, Yamamoto, Ami, Stewart, Ron, Thomson, James A., Kyba, Michael, Perlingeiro, Rita C. R.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2019
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410870/
https://ncbi.nlm.nih.gov/pubmed/30760602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1808303116
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