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PGC1A regulates the IRS1:IRS2 ratio during fasting to influence hepatic metabolism downstream of insulin

Precise modulation of hepatic glucose metabolism is crucial during the fasting and feeding cycle and is controlled by the actions of circulating insulin and glucagon. The insulin-signaling pathway requires insulin receptor substrate 1 (IRS1) and IRS2, which are found to be dysregulated in diabetes a...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Besse-Patin, Aurèle, Jeromson, Stewart, Levesque-Damphousse, Philipa, Secco, Blandine, Laplante, Mathieu, Estall, Jennifer L.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410797/
https://ncbi.nlm.nih.gov/pubmed/30770439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1815150116
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