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Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation
Diabetes risk increases significantly with age and correlates with lower oxidative capacity in muscle. Decreased expression of peroxisome proliferator-activated receptor-γ coactivator-1α (Pgc-1α) and target gene pathways involved in mitochondrial oxidative phosphorylation are associated with muscle...
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| 主要な著者: | , , , , , , , , |
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| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
American Physiological Society
2013
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4073996/ https://ncbi.nlm.nih.gov/pubmed/24280126 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00578.2013 |
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