Loss of Pgc-1α expression in aging mouse muscle potentiates glucose intolerance and systemic inflammation

Diabetes risk increases significantly with age and correlates with lower oxidative capacity in muscle. Decreased expression of peroxisome proliferator-activated receptor-γ coactivator-1α (Pgc-1α) and target gene pathways involved in mitochondrial oxidative phosphorylation are associated with muscle...

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Main Authors: Sczelecki, Sarah, Besse-Patin, Aurèle, Abboud, Alexandra, Kleiner, Sandra, Laznik-Bogoslavski, Dina, Wrann, Christiane D., Ruas, Jorge L., Haibe-Kains, Benjamin, Estall, Jennifer L.
Formato: Artigo
Idioma:Inglês
Publicado: American Physiological Society 2013
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4073996/
https://ncbi.nlm.nih.gov/pubmed/24280126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajpendo.00578.2013
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