Učitavanje...
The pharmacology of second-generation chimeric antigen receptors
Second generation chimeric antigen receptors (CARs) retarget and reprogram T lymphocytes to augment their anti-tumour efficacy. The combined activating and costimulatory domains incorporated in these CARs critically determine the function, differentiation, metabolism and persistence of engineered T...
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| Izdano u: | Nat Rev Drug Discov |
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| Glavni autori: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2015
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| Teme: | |
| Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6410718/ https://ncbi.nlm.nih.gov/pubmed/26129802 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nrd4597 |
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