Integrating proteomics and transcriptomics for systematic combinatorial chimeric antigen receptor therapy of AML

Chimeric antigen receptor (CAR) therapy targeting CD19 has yielded remarkable outcomes in patients with acute lymphoblastic leukemia. To identify potential CAR targets in acute myeloid leukemia (AML), we probed the AML surfaceome for over-expressed molecules with tolerable systemic expression. We in...

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Gepubliceerd in:Cancer Cell
Hoofdauteurs: Perna, Fabiana, Berman, Samuel, Soni, Rajesh, Mansilla-Soto, Jorge, Eyquem, Justin, Hamieh, Mohamad, Hendrickson, Ronald, Brennan, Cameron, Sadelain, Michel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2017
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7025434/
https://ncbi.nlm.nih.gov/pubmed/29017060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ccell.2017.09.004
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