A population pharmacokinetic/toxicity model for the reduction of platelets during a 48-h continuous intravenous infusion of the histone deacetylase inhibitor belinostat

PURPOSE: Belinostat is a second-generation histone deacetylase inhibitor (HDI) predominantly metabolized by UGT1A1-mediated glucuronidation. Two common polymorphisms (UGT1A1*28 and UGT1A1*60) were previously associated with impaired drug clearance and thrombocytopenia risk, likely form increased dru...

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Bibliografiset tiedot
Julkaisussa:Cancer Chemother Pharmacol
Päätekijät: Peer, Cody J., Hall, Oliver M., Sissung, Tristan M., Piekarz, Richard, Balasubramaniam, Sanjeeve, Bates, Susan E., Figg, William D.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: 2018
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410699/
https://ncbi.nlm.nih.gov/pubmed/29951694
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00280-018-3631-7
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