Effects of UGT1A1 Genotype on the Pharmacokinetics, Pharmacodynamics, and Toxicities of Belinostat Administered by 48-Hour Continuous Infusion in Patients With Cancer

The histone deacetylase inhibitor belinostat is eliminated through glucuronidation by UGTIAI. Polymorphisms that reduce UGTIAI function could result in increased belinostat exposure and toxicities. We wanted to determine which single-nucleotide polymorphisms alter belinostat exposure and toxicity. I...

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Bibliografiska uppgifter
I publikationen:J Clin Pharmacol
Huvudupphovsmän: Goey, Andrew K. L., Sissung, Tristan M., Peer, Cody J., Trepel, Jane B., Lee, Min-Jung, Tomita, Yusuke, Ehrlich, Sheryl, Bryla, Christine, Balasubramaniam, Sanjeeve, Piekarz, Richard, Steinberg, Seth M., Bates, Susan E., Figg, William D.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC6361127/
https://ncbi.nlm.nih.gov/pubmed/26313268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.625
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