Effects of UGT1A1 Genotype on the Pharmacokinetics, Pharmacodynamics, and Toxicities of Belinostat Administered by 48-Hour Continuous Infusion in Patients With Cancer

The histone deacetylase inhibitor belinostat is eliminated through glucuronidation by UGTIAI. Polymorphisms that reduce UGTIAI function could result in increased belinostat exposure and toxicities. We wanted to determine which single-nucleotide polymorphisms alter belinostat exposure and toxicity. I...

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Publicat a:J Clin Pharmacol
Autors principals: Goey, Andrew K. L., Sissung, Tristan M., Peer, Cody J., Trepel, Jane B., Lee, Min-Jung, Tomita, Yusuke, Ehrlich, Sheryl, Bryla, Christine, Balasubramaniam, Sanjeeve, Piekarz, Richard, Steinberg, Seth M., Bates, Susan E., Figg, William D.
Format: Artigo
Idioma:Inglês
Publicat: 2015
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6361127/
https://ncbi.nlm.nih.gov/pubmed/26313268
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcph.625
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