Epsins Regulate Mouse Embryonic Stem Cell Exit from Pluripotency and Neural Commitment by Controlling Notch Activation

Epsins are part of the internalization machinery pivotal to control clathrin-mediated endocytosis. Here, we report that epsin family members are expressed in mouse embryonic stem cells (mESCs) and that epsin1/2 knockdown alters both mESC exits from pluripotency and their differentiation. Furthermore...

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Vydáno v:Stem Cells Int
Hlavní autoři: Cardano, Marina, Zasso, Jacopo, Ruggiero, Luca, Di Giacomo, Giuseppina, Marcatili, Matteo, Cremona, Ottavio, Conti, Luciano
Médium: Artigo
Jazyk:Inglês
Vydáno: Hindawi 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6410434/
https://ncbi.nlm.nih.gov/pubmed/30930949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/4084351
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