PIAS4 regulates pluripotency exit and cell fate commitment in porcine embryonic stem cells

Post-translational modifications (PTMs) are dynamic processes that regulate cell states by enhancing proteome diversity. However, the overall impact of PTMs on pluripotency exit in porcine embryonic stem cells (pESCs) remains largely unknown. Here, we present a systematic assay to identify E3 ubiqui...

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Detalhes bibliográficos

Principais autores:	Wei Qin, Yu Wang, Hongfei Duan, Qiao Li, Dagang Tao, Peng Su, Linhui Wu, Delong Li, Tian Xu, Shengsong Xie, Xia Zhang, Jilong Zhou, Yi-Liang Miao
Formato:	Artigo
Idioma:	Inglês
Publicado em:	KeAi Communications Co. Ltd. 2025-07-01
coleção:	Fundamental Research
Assuntos:	Pluripotency exit porcine Extended Potential Stem Cells PIAS4 CRISPR screening Post-transcriptional modification Ubiquitin ligase
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S2667325824004473
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