PIAS4 regulates pluripotency exit and cell fate commitment in porcine embryonic stem cells

Post-translational modifications (PTMs) are dynamic processes that regulate cell states by enhancing proteome diversity. However, the overall impact of PTMs on pluripotency exit in porcine embryonic stem cells (pESCs) remains largely unknown. Here, we present a systematic assay to identify E3 ubiqui...

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Autors principals:	Wei Qin, Yu Wang, Hongfei Duan, Qiao Li, Dagang Tao, Peng Su, Linhui Wu, Delong Li, Tian Xu, Shengsong Xie, Xia Zhang, Jilong Zhou, Yi-Liang Miao
Format:	Artigo
Idioma:	Inglês
Publicat:	KeAi Communications Co. Ltd. 2025-07-01
Col·lecció:	Fundamental Research
Matèries:	Pluripotency exit porcine Extended Potential Stem Cells PIAS4 CRISPR screening Post-transcriptional modification Ubiquitin ligase
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S2667325824004473
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