Embryonic arrest at midgestation and disruption of Notch signaling produced by the absence of both epsin 1 and epsin 2 in mice

Epsins are endocytic adaptors with putative functions in general aspects of clathrin-mediated endocytosis as well as in the internalization of specific membrane proteins. We have now tested the role of the ubiquitously expressed epsin genes, Epn1 and Epn2, by a genetic approach in mice. While either...

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Bibliografiske detaljer
Main Authors: Chen, Hong, Ko, Genevieve, Zatti, Alessandra, Di Giacomo, Giuseppina, Liu, Lijuan, Raiteri, Elisabetta, Perucco, Ezio, Collesi, Chiara, Min, Wang, Zeiss, Caroline, De Camilli, Pietro, Cremona, Ottavio
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2009
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2728981/
https://ncbi.nlm.nih.gov/pubmed/19666558
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0907008106
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