A Human Skin Model Recapitulates Systemic Sclerosis Dermal Fibrosis and Identifies COL22A1 as a TGFβ Early Response Gene that Mediates Fibroblast to Myofibroblast Transition

Systemic sclerosis (SSc) is a complex multi-system autoimmune disease characterized by immune dysregulation, vasculopathy, and organ fibrosis. Skin fibrosis causes high morbidity and impaired quality of life in affected individuals. Animal models do not fully recapitulate the human disease. Thus, th...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Genes (Basel)
Prif Awduron: Watanabe, Tomoya, Baker Frost, DeAnna, Mlakar, Logan, Heywood, Jonathan, da Silveira, Willian A., Hardiman, Gary, Feghali-Bostwick, Carol
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: MDPI 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6409682/
https://ncbi.nlm.nih.gov/pubmed/30678304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes10020075
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