A Human Skin Model Recapitulates Systemic Sclerosis Dermal Fibrosis and Identifies COL22A1 as a TGFβ Early Response Gene that Mediates Fibroblast to Myofibroblast Transition

Systemic sclerosis (SSc) is a complex multi-system autoimmune disease characterized by immune dysregulation, vasculopathy, and organ fibrosis. Skin fibrosis causes high morbidity and impaired quality of life in affected individuals. Animal models do not fully recapitulate the human disease. Thus, th...

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Bibliografische gegevens
Gepubliceerd in:Genes (Basel)
Hoofdauteurs: Watanabe, Tomoya, Baker Frost, DeAnna, Mlakar, Logan, Heywood, Jonathan, da Silveira, Willian A., Hardiman, Gary, Feghali-Bostwick, Carol
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI 2019
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6409682/
https://ncbi.nlm.nih.gov/pubmed/30678304
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes10020075
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