Proliferative and Antiapoptotic Signaling Stimulated by Nuclear-Localized PDK1 Results in Oncogenesis

Enhanced activation of phosphoinositide 3-kinase (PI3K) is a hallmark of many human tumors because it promotes cell proliferation and survival through several mechanisms. One of these mechanisms is the phosphorylation of the serine and threonine kinase Akt at the cytosolic side of the plasma membran...

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發表在:Sci Signal
Main Authors: Kikani, Chintan K., Verona, Erik V., Ryu, Jiyoon, Shen, Yanying, Ye, Qingqing, Zheng, Li, Qian, Ziliang, Sakaue, Hiroshi, Nakamura, Kyoko, Du, Jie, Ji, Qunsheng, Ogawa, Wataru, Sun, Lu-Zhe, Dong, Lily Q., Liu, Feng
格式: Artigo
語言:Inglês
出版: 2012
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408955/
https://ncbi.nlm.nih.gov/pubmed/23131847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003065
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