Proliferative and Antiapoptotic Signaling Stimulated by Nuclear-Localized PDK1 Results in Oncogenesis

Enhanced activation of phosphoinositide 3-kinase (PI3K) is a hallmark of many human tumors because it promotes cell proliferation and survival through several mechanisms. One of these mechanisms is the phosphorylation of the serine and threonine kinase Akt at the cytosolic side of the plasma membran...

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Dades bibliogràfiques
Publicat a:Sci Signal
Autors principals: Kikani, Chintan K., Verona, Erik V., Ryu, Jiyoon, Shen, Yanying, Ye, Qingqing, Zheng, Li, Qian, Ziliang, Sakaue, Hiroshi, Nakamura, Kyoko, Du, Jie, Ji, Qunsheng, Ogawa, Wataru, Sun, Lu-Zhe, Dong, Lily Q., Liu, Feng
Format: Artigo
Idioma:Inglês
Publicat: 2012
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408955/
https://ncbi.nlm.nih.gov/pubmed/23131847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003065
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