Proliferative and Antiapoptotic Signaling Stimulated by Nuclear-Localized PDK1 Results in Oncogenesis

Enhanced activation of phosphoinositide 3-kinase (PI3K) is a hallmark of many human tumors because it promotes cell proliferation and survival through several mechanisms. One of these mechanisms is the phosphorylation of the serine and threonine kinase Akt at the cytosolic side of the plasma membran...

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Pubblicato in:Sci Signal
Autori principali: Kikani, Chintan K., Verona, Erik V., Ryu, Jiyoon, Shen, Yanying, Ye, Qingqing, Zheng, Li, Qian, Ziliang, Sakaue, Hiroshi, Nakamura, Kyoko, Du, Jie, Ji, Qunsheng, Ogawa, Wataru, Sun, Lu-Zhe, Dong, Lily Q., Liu, Feng
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408955/
https://ncbi.nlm.nih.gov/pubmed/23131847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scisignal.2003065
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