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Structure guided design of an antibacterial peptide that targets UDP-N-acetylglucosamine acyltransferase
UDP-N-acetylglucosamine (UDP-GlcNAc) acyltransferase (LpxA) catalyzes the first step of lipid A biosynthesis, the transfer of an R-3-hydroxyacyl chain from its acyl carrier protein (ACP) to the 3-OH group of UDP-GlcNAc. Essential in the growth of Gram-negative bacteria, LpxA is a logical target for...
Shranjeno v:
| izdano v: | Sci Rep |
|---|---|
| Main Authors: | , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Nature Publishing Group UK
2019
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6408518/ https://ncbi.nlm.nih.gov/pubmed/30850651 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-40418-8 |
| Oznake: |
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