HLA class II antibodies induce necrotic cell death in human endothelial cells via a lysosomal membrane permeabilization-mediated pathway

Antibody-mediated rejection (AMR) is the major cause of allograft loss after solid organ transplantation. Circulating donor-specific antibodies against human leukocyte antigen (HLA), in particular HLA class II antibodies are critical for the pathogenesis of AMR via interactions with endothelial cell...

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Publicado en:Cell Death Dis
Main Authors: Aljabri, Abid, Vijayan, Vijith, Stankov, Metodi, Nikolin, Christoph, Figueiredo, Constanca, Blasczyk, Rainer, Becker, Jan Ulrich, Linkermann, Andreas, Immenschuh, Stephan
Formato: Artigo
Idioma:Inglês
Publicado: Nature Publishing Group UK 2019
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6408495/
https://ncbi.nlm.nih.gov/pubmed/30850581
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1319-5
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