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An Assembly-activating Site in the Hepatitis B Virus Capsid Protein can also Trigger Disassembly
The Hepatitis B Virus (HBV) core protein homodimers self-assemble to form an icosahedral capsid that packages the viral genome. Disassembly occurs in the nuclear basket to release the mature genome to the nucleus. Small molecules have been developed that bind to a pocket at the inter-dimer interface...
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| Publicado no: | ACS Chem Biol |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6407610/ https://ncbi.nlm.nih.gov/pubmed/29920071 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acschembio.8b00283 |
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