A heteroaryldihydropyrimidine activates and can misdirect hepatitis B virus capsid assembly

Heteroaryldihydropyrimidines (HAPs) are a new class of antivirals inhibiting production of hepatitis B virus (HBV) virions in tissue culture. Here, we examine the effect of a representative HAP molecule, methyl 4-(2-chloro-4-fluorophenyl)-6-methyl-2-(pyridin-2-yl)-1,4-dihydropyrimidine-5-carboxylate...

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Main Authors: Stray, Stephen J., Bourne, Christina R., Punna, Sreenivas, Lewis, Warren G., Finn, M. G., Zlotnick, Adam
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2005
Assuntos:
Biological Sciences
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC1149411/
https://ncbi.nlm.nih.gov/pubmed/15928089
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0409732102
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