Hepatitis B virus core protein allosteric modulators can distort and disrupt intact capsids

Defining mechanisms of direct-acting antivirals facilitates drug development and our understanding of virus function. Heteroaryldihydropyrimidines (HAPs) inappropriately activate assembly of hepatitis B virus (HBV) core protein (Cp), suppressing formation of virions. We examined a fluorophore-labele...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:eLife
Päätekijät: Schlicksup, Christopher John, Wang, Joseph Che-Yen, Francis, Samson, Venkatakrishnan, Balasubramanian, Turner, William W, VanNieuwenhze, Michael, Zlotnick, Adam
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: eLife Sciences Publications, Ltd 2018
Aiheet:
Biochemistry and Chemical Biology
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5788503/
https://ncbi.nlm.nih.gov/pubmed/29377794
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.31473
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