Structural Differences between the Woodchuck Hepatitis Virus Core Protein in the Dimer and Capsid States Are Consistent with Entropic and Conformational Regulation of Assembly

Hepadnaviruses are hepatotropic enveloped DNA viruses with an icosahedral capsid. Hepatitis B virus (HBV) causes chronic infection in an estimated 240 million people; woodchuck hepatitis virus (WHV), an HBV homologue, has been an important model system for drug development. The dimeric capsid protei...

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Publicado en:J Virol
Autores principales: Zhao, Zhongchao, Wang, Joseph Che-Yen, Gonzalez-Gutierrez, Giovanni, Venkatakrishnan, Balasubramanian, Asor, Roi, Khaykelson, Daniel, Raviv, Uri, Zlotnick, Adam
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2019
Materias:
Structure and Assembly
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6600186/
https://ncbi.nlm.nih.gov/pubmed/31043524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00141-19
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