Structural Differences between the Woodchuck Hepatitis Virus Core Protein in the Dimer and Capsid States Are Consistent with Entropic and Conformational Regulation of Assembly

Hepadnaviruses are hepatotropic enveloped DNA viruses with an icosahedral capsid. Hepatitis B virus (HBV) causes chronic infection in an estimated 240 million people; woodchuck hepatitis virus (WHV), an HBV homologue, has been an important model system for drug development. The dimeric capsid protei...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Zhao, Zhongchao, Wang, Joseph Che-Yen, Gonzalez-Gutierrez, Giovanni, Venkatakrishnan, Balasubramanian, Asor, Roi, Khaykelson, Daniel, Raviv, Uri, Zlotnick, Adam
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Structure and Assembly
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6600186/
https://ncbi.nlm.nih.gov/pubmed/31043524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00141-19
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