Structural Differences between the Woodchuck Hepatitis Virus Core Protein in the Dimer and Capsid States Are Consistent with Entropic and Conformational Regulation of Assembly

Hepadnaviruses are hepatotropic enveloped DNA viruses with an icosahedral capsid. Hepatitis B virus (HBV) causes chronic infection in an estimated 240 million people; woodchuck hepatitis virus (WHV), an HBV homologue, has been an important model system for drug development. The dimeric capsid protei...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Virol
Main Authors: Zhao, Zhongchao, Wang, Joseph Che-Yen, Gonzalez-Gutierrez, Giovanni, Venkatakrishnan, Balasubramanian, Asor, Roi, Khaykelson, Daniel, Raviv, Uri, Zlotnick, Adam
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2019
Teme:
Structure and Assembly
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6600186/
https://ncbi.nlm.nih.gov/pubmed/31043524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00141-19
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