Loss-of-Huntingtin in Medial and Lateral Ganglionic Lineages Differentially Disrupts Regional Interneuron and Projection Neuron Subtypes and Promotes Huntington's Disease-Associated Behavioral, Cellular, and Pathological Hallmarks

Emerging studies are providing compelling evidence that the pathogenesis of Huntington's disease (HD), a neurodegenerative disorder with frequent midlife onset, encompasses developmental components. Moreover, our previous studies using a hypomorphic model targeting huntingtin during the neurode...

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Veröffentlicht in:J Neurosci
Hauptverfasser: Mehler, Mark F., Petronglo, Jenna R., Arteaga-Bracho, Eduardo E., Gulinello, Maria E., Winchester, Michael L., Pichamoorthy, Nandini, Young, Stephen K., DeJesus, Christopher D., Ishtiaq, Hifza, Gokhan, Solen, Molero, Aldrin E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Society for Neuroscience 2019
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Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407290/
https://ncbi.nlm.nih.gov/pubmed/30626701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2443-18.2018
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