Role of RASEF hypermethylation in cigarette smoke-induced pulmonary arterial smooth muscle remodeling

BACKGROUND: Pulmonary hypertension (PH) is a progressive and fatal disease. While cigarette smoke can change DNA methylation status, the role of such molecular alterations in smoke-associated PH is unclear. METHODS: A PH rat model was developed by exposing animals to cigarette smoke for 3 months. Ri...

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Veröffentlicht in:Respir Res
Hauptverfasser: Li, Qinghai, Wu, Jixing, Xu, Yongjian, Liu, Lu, Xie, Jungang
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2019
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6407244/
https://ncbi.nlm.nih.gov/pubmed/30845941
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12931-019-1014-1
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