27-Hydroxycholesterol Contributes to Lysosomal Membrane Permeabilization-Mediated Pyroptosis in Co-cultured SH-SY5Y Cells and C6 Cells

Purpose: Emerging evidence suggests that 27-Hydroxycholesterol (27-OHC) causes neurodegenerative diseases through the induction of cytotoxicity and cholesterol metabolism disorder. The objective of this study is to determine the impacts of 27-OHC on lysosomal membrane permeabilization (LMP) and pyro...

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Vydáno v:Front Mol Neurosci
Hlavní autoři: Chen, Si, Zhou, Cui, Yu, Huiyan, Tao, Lingwei, An, Yu, Zhang, Xiaona, Wang, Ying, Wang, Yushan, Xiao, Rong
Médium: Artigo
Jazyk:Inglês
Vydáno: Frontiers Media S.A. 2019
Témata:
Neuroscience
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6405519/
https://ncbi.nlm.nih.gov/pubmed/30881285
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2019.00014
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