27‐hydroxycholesterol promotes Aβ accumulation via altering Aβ metabolism in mild cognitive impairment patients and APP/PS1 mice

The oxysterol 27‐hydroxycholesterol (27‐OHC) has been considered to play a key role in the pathogenesis of Alzheimer’s disease (AD). Because β‐amyloid peptide (Aβ) is the pathological hallmark of AD, the aim of this study is to verify whether 27‐OHC could lead to cognitive impairment through modulat...

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Dades bibliogràfiques
Publicat a:Brain Pathol
Autors principals: Zhang, Xiaona, Xi, Yuandi, Yu, Huiyan, An, Yu, Wang, Ying, Tao, Lingwei, Wang, Yushan, Liu, Wen, Wang, Tao, Xiao, Rong
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC8028629/
https://ncbi.nlm.nih.gov/pubmed/30582229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12698
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