27‐hydroxycholesterol promotes Aβ accumulation via altering Aβ metabolism in mild cognitive impairment patients and APP/PS1 mice

The oxysterol 27‐hydroxycholesterol (27‐OHC) has been considered to play a key role in the pathogenesis of Alzheimer’s disease (AD). Because β‐amyloid peptide (Aβ) is the pathological hallmark of AD, the aim of this study is to verify whether 27‐OHC could lead to cognitive impairment through modulat...

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Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Brain Pathol
Asıl Yazarlar: Zhang, Xiaona, Xi, Yuandi, Yu, Huiyan, An, Yu, Wang, Ying, Tao, Lingwei, Wang, Yushan, Liu, Wen, Wang, Tao, Xiao, Rong
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: John Wiley and Sons Inc. 2019
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC8028629/
https://ncbi.nlm.nih.gov/pubmed/30582229
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12698
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