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27‐hydroxycholesterol promotes Aβ accumulation via altering Aβ metabolism in mild cognitive impairment patients and APP/PS1 mice
The oxysterol 27‐hydroxycholesterol (27‐OHC) has been considered to play a key role in the pathogenesis of Alzheimer’s disease (AD). Because β‐amyloid peptide (Aβ) is the pathological hallmark of AD, the aim of this study is to verify whether 27‐OHC could lead to cognitive impairment through modulat...
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| Publicado no: | Brain Pathol |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
John Wiley and Sons Inc.
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8028629/ https://ncbi.nlm.nih.gov/pubmed/30582229 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/bpa.12698 |
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