Integrated Functional Genomic Analysis Enables Annotation of Kidney Genome-Wide Association Study Loci

BACKGROUND: Linking genetic risk loci identified by genome-wide association studies (GWAS) to their causal genes remains a major challenge. Disease-associated genetic variants are concentrated in regions containing regulatory DNA elements, such as promoters and enhancers. Although researchers have p...

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Vydáno v:J Am Soc Nephrol
Hlavní autoři: Sieber, Karsten B., Batorsky, Anna, Siebenthall, Kyle, Hudkins, Kelly L., Vierstra, Jeff D., Sullivan, Shawn, Sur, Aakash, McNulty, Michelle, Sandstrom, Richard, Reynolds, Alex, Bates, Daniel, Diegel, Morgan, Dunn, Douglass, Nelson, Jemma, Buckley, Michael, Kaul, Rajinder, Sampson, Matthew G., Himmelfarb, Jonathan, Alpers, Charles E., Waterworth, Dawn, Akilesh, Shreeram
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Nephrology 2019
Témata:
Basic Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6405142/
https://ncbi.nlm.nih.gov/pubmed/30760496
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1681/ASN.2018030309
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