Single-Cell Approach to Monitor the Unfolded Protein Response During Biotechnological Processes With Pichia pastoris

Pichia pastoris (Komagataella sp.) is broadly used for the production of secreted recombinant proteins. Due to the high rate of protein production, incorrectly folded proteins may accumulate in the endoplasmic reticulum (ER). To restore their proper folding, the cell triggers the unfolded protein re...

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Dades bibliogràfiques
Publicat a:Front Microbiol
Autors principals: Raschmanová, Hana, Zamora, Iwo, Borčinová, Martina, Meier, Patrick, Weninger, Astrid, Mächler, Dominik, Glieder, Anton, Melzoch, Karel, Knejzlík, Zdeněk, Kovar, Karin
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2019
Matèries:
Microbiology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404689/
https://ncbi.nlm.nih.gov/pubmed/30873140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.00335
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