Single-Cell Approach to Monitor the Unfolded Protein Response During Biotechnological Processes With Pichia pastoris

Pichia pastoris (Komagataella sp.) is broadly used for the production of secreted recombinant proteins. Due to the high rate of protein production, incorrectly folded proteins may accumulate in the endoplasmic reticulum (ER). To restore their proper folding, the cell triggers the unfolded protein re...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Raschmanová, Hana, Zamora, Iwo, Borčinová, Martina, Meier, Patrick, Weninger, Astrid, Mächler, Dominik, Glieder, Anton, Melzoch, Karel, Knejzlík, Zdeněk, Kovar, Karin
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404689/
https://ncbi.nlm.nih.gov/pubmed/30873140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.00335
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