Single-Cell Approach to Monitor the Unfolded Protein Response During Biotechnological Processes With Pichia pastoris

Pichia pastoris (Komagataella sp.) is broadly used for the production of secreted recombinant proteins. Due to the high rate of protein production, incorrectly folded proteins may accumulate in the endoplasmic reticulum (ER). To restore their proper folding, the cell triggers the unfolded protein re...

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Bibliografski detalji
Izdano u:Front Microbiol
Glavni autori: Raschmanová, Hana, Zamora, Iwo, Borčinová, Martina, Meier, Patrick, Weninger, Astrid, Mächler, Dominik, Glieder, Anton, Melzoch, Karel, Knejzlík, Zdeněk, Kovar, Karin
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Microbiology
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404689/
https://ncbi.nlm.nih.gov/pubmed/30873140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.00335
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