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Engineering of the unfolded protein response pathway in Pichia pastoris: enhancing production of secreted recombinant proteins
ABSTRACT: Folding and processing of proteins in the endoplasmic reticulum (ER) are major impediments in the production and secretion of proteins from Pichia pastoris (Komagataella sp.). Overexpression of recombinant genes can overwhelm the innate secretory machinery of the P. pastoris cell, and inco...
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| 出版年: | Appl Microbiol Biotechnol |
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| 主要な著者: | , , , , |
| フォーマット: | Artigo |
| 言語: | Inglês |
| 出版事項: |
Springer Berlin Heidelberg
2021
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| 主題: | |
| オンライン･アクセス: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8195892/ https://ncbi.nlm.nih.gov/pubmed/34037840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-021-11336-5 |
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