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Engineering of the unfolded protein response pathway in Pichia pastoris: enhancing production of secreted recombinant proteins
ABSTRACT: Folding and processing of proteins in the endoplasmic reticulum (ER) are major impediments in the production and secretion of proteins from Pichia pastoris (Komagataella sp.). Overexpression of recombinant genes can overwhelm the innate secretory machinery of the P. pastoris cell, and inco...
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| Pubblicato in: | Appl Microbiol Biotechnol |
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| Autori principali: | , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
Springer Berlin Heidelberg
2021
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC8195892/ https://ncbi.nlm.nih.gov/pubmed/34037840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00253-021-11336-5 |
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