NF-κB p65 dimerization and DNA-binding is important for inflammatory gene expression

Increasing evidence shows that many transcription factors execute important biologic functions independent from their DNA-binding capacity. The NF-κB p65 (RELA) subunit is a central regulator of innate immunity. Here, we investigated the relative functional contribution of p65 DNA-binding and dimeri...

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Publicat a:FASEB J
Autors principals: Riedlinger, Tabea, Liefke, Robert, Meier-Soelch, Johanna, Jurida, Liane, Nist, Andrea, Stiewe, Thorsten, Kracht, Michael, Schmitz, M. Lienhard
Format: Artigo
Idioma:Inglês
Publicat: Federation of American Societies for Experimental Biology 2019
Matèries:
Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404571/
https://ncbi.nlm.nih.gov/pubmed/30526044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.201801638R
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