CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain

BACKGROUND: Tumour cells rely on glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) to survive. Thus, mitochondrial OXPHOS has become an increasingly attractive area for therapeutic exploitation in cancer. However, mitochondria are required for intracellular oxygenation and normal physi...

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Опубликовано в: :Cancer Metab
Главные авторы: Thomas, Luke W., Stephen, Jenna M., Esposito, Cinzia, Hoer, Simon, Antrobus, Robin, Ahmed, Afshan, Al-Habib, Hasan, Ashcroft, Margaret
Формат: Artigo
Язык:Inglês
Опубликовано: BioMed Central 2019
Предметы:
Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404347/
https://ncbi.nlm.nih.gov/pubmed/30886710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-019-0194-y
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