CHCHD4 confers metabolic vulnerabilities to tumour cells through its control of the mitochondrial respiratory chain

BACKGROUND: Tumour cells rely on glycolysis and mitochondrial oxidative phosphorylation (OXPHOS) to survive. Thus, mitochondrial OXPHOS has become an increasingly attractive area for therapeutic exploitation in cancer. However, mitochondria are required for intracellular oxygenation and normal physi...

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Enregistré dans:
Détails bibliographiques
Publié dans:Cancer Metab
Auteurs principaux: Thomas, Luke W., Stephen, Jenna M., Esposito, Cinzia, Hoer, Simon, Antrobus, Robin, Ahmed, Afshan, Al-Habib, Hasan, Ashcroft, Margaret
Format: Artigo
Langue:Inglês
Publié: BioMed Central 2019
Sujets:
Research
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6404347/
https://ncbi.nlm.nih.gov/pubmed/30886710
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40170-019-0194-y
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