Identification of Novel Inhibitors of DLK Palmitoylation and Signaling by High Content Screening

After axonal insult and injury, Dual leucine-zipper kinase (DLK) conveys retrograde pro-degenerative signals to neuronal cell bodies via its downstream target c-Jun N-terminal kinase (JNK). We recently reported that such signals critically require modification of DLK by the fatty acid palmitate, via...

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Publicado no:Sci Rep
Main Authors: Martin, Dale D. O., Kanuparthi, Prasad S., Holland, Sabrina M., Sanders, Shaun S., Jeong, Hey-Kyeong, Einarson, Margret B., Jacobson, Marlene A., Thomas, Gareth M.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403299/
https://ncbi.nlm.nih.gov/pubmed/30842471
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39968-8
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