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Palmitoylation controls DLK localization, interactions and activity to ensure effective axonal injury signaling
Dual leucine-zipper kinase (DLK) is critical for axon-to-soma retrograde signaling following nerve injury. However, it is unknown how DLK, a predicted soluble kinase, conveys long-distance signals and why homologous kinases cannot compensate for loss of DLK. Here, we report that DLK, but not homolog...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2016
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4725513/ https://ncbi.nlm.nih.gov/pubmed/26719418 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514123113 |
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