Palmitoylation controls DLK localization, interactions and activity to ensure effective axonal injury signaling

Dual leucine-zipper kinase (DLK) is critical for axon-to-soma retrograde signaling following nerve injury. However, it is unknown how DLK, a predicted soluble kinase, conveys long-distance signals and why homologous kinases cannot compensate for loss of DLK. Here, we report that DLK, but not homolog...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Holland, Sabrina M., Collura, Kaitlin M., Ketschek, Andrea, Noma, Kentaro, Ferguson, Toby A., Jin, Yishi, Gallo, Gianluca, Thomas, Gareth M.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2016
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4725513/
https://ncbi.nlm.nih.gov/pubmed/26719418
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1514123113
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