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Identification of Novel Inhibitors of DLK Palmitoylation and Signaling by High Content Screening
After axonal insult and injury, Dual leucine-zipper kinase (DLK) conveys retrograde pro-degenerative signals to neuronal cell bodies via its downstream target c-Jun N-terminal kinase (JNK). We recently reported that such signals critically require modification of DLK by the fatty acid palmitate, via...
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| Udgivet i: | Sci Rep |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Nature Publishing Group UK
2019
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6403299/ https://ncbi.nlm.nih.gov/pubmed/30842471 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-39968-8 |
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