ABHD5 blunts the sensitivity of colorectal cancer to fluorouracil via promoting autophagic uracil yield

The efficacy of Fluorouracil (FU) in the treatment of colorectal cancer (CRC) is greatly limited by drug resistance. Autophagy has been implicated in chemoresistance, but the role of selective autophagic degradation in regulating chemoresistance remains unknown. In this study, we revealed a critical...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Ou, Juanjuan, Peng, Yuan, Yang, Weiwen, Zhang, Yue, Hao, Jie, Li, Fu, Chen, Yanrong, Zhao, Yang, Xie, Xiong, Wu, Shuang, Zha, Lin, Luo, Xi, Xie, Ganfeng, Wang, Liting, Sun, Wei, Zhou, Qi, Li, Jianjun, Liang, Houjie
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403256/
https://ncbi.nlm.nih.gov/pubmed/30842415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-08902-x
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