Synergistic Antitumor Effect of Dichloroacetate in Combination with 5-Fluorouracil in Colorectal Cancer

Dichloroacetate (DCA), an inhibitor of pyruvate dehydrogenase kinase (PDK), has been recently demonstrated as a promising nontoxic antineoplastic agent that promotes apoptosis of cancer cells. In the present study, we aimed to investigate the antitumor effect of DCA combined with 5-Fluorouracil (5-F...

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Bibliographic Details
Main Authors: Tong, Jingtao, Xie, Ganfeng, He, Jinxia, Li, Jianjun, Pan, Feng, Liang, Houjie
Format: Artigo
Language:Inglês
Published: Hindawi Publishing Corporation 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3043319/
https://ncbi.nlm.nih.gov/pubmed/21403907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2011/740564
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