Synergistic antitumor effect of 5-fluorouracil with the novel LSD1 inhibitor ZY0511 in colorectal cancer

BACKGROUND: Lysine-specific histone demethylase 1 (LSD1) is a potential target of cancer therapy. In the present study, we aimed to investigate the combined antitumor activity of a novel LSD1 inhibitor (ZY0511) with 5-fluorouracil (5-FU) and elucidate the underlying mechanism in colorectal cancer (C...

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Bibliographische Detailangaben
Veröffentlicht in:Ther Adv Med Oncol
Hauptverfasser: Peng, Wen, Zhang, Huaqing, Tan, Shisheng, Li, Yan, Zhou, Yang, Wang, Liang, Liu, Chunqi, Li, Qiu, Cen, Xiaobo, Yang, Shengyong, Zhao, Yinglan
Format: Artigo
Sprache:Inglês
Veröffentlicht: SAGE Publications 2020
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7378962/
https://ncbi.nlm.nih.gov/pubmed/32754230
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/1758835920937428
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