Targeting the Hexosamine Biosynthetic Pathway Prevents Plasmodium Developmental Cycle and Disease Pathology in Vertebrate Host

Cerebral malaria (CM) is a clinical syndrome involving irreversible and lethal signs of brain injury associated to infection by parasites of the genus Plasmodium. The pathogenesis of CM derives from infection-induced proinflammatory cytokines associated with cytoadherence of parasitized red blood ce...

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Bibliographic Details
Published in:Front Microbiol
Main Authors: Gomes, Pollyanna Stephanie, Tanghe, Scott, Gallego-Delgado, Julio, Conde, Luciana, Freire-de-Lima, Leonardo, Lima, Ana Carolina, Freire-de-Lima, Célio Geraldo, Lima Junior, Josué da Costa, Moreira, Otacílio, Totino, Paulo, Rodriguez, Ana, Todeschini, Adriane Regina, Morrot, Alexandre
Format: Artigo
Language:Inglês
Published: Frontiers Media S.A. 2019
Subjects:
Microbiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403127/
https://ncbi.nlm.nih.gov/pubmed/30873136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.00305
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