Positive N-Methyl-D-Aspartate Receptor Modulation by Rapastinel Promotes Rapid and Sustained Antidepressant-Like Effects

BACKGROUND: Modulation of glutamatergic synaptic transmission by N-methyl-D-aspartate receptors can produce rapid and sustained antidepressant effects. Rapastinel (GLYX-13), initially described as a N-methyl-D-aspartate receptor partial glycine site agonist, exhibits rapid antidepressant effect in r...

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Detalhes bibliográficos
Publicado no:Int J Neuropsychopharmacol
Main Authors: Donello, John E, Banerjee, Pradeep, Li, Yong-Xin, Guo, Yuan-Xing, Yoshitake, Takashi, Zhang, Xiao-Lei, Miry, Omid, Kehr, Jan, Stanton, Patric K, Gross, Amanda L, Burgdorf, Jeffery S, Kroes, Roger A, Moskal, Joseph R
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2018
Assuntos:
Regular Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6403082/
https://ncbi.nlm.nih.gov/pubmed/30544218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/ijnp/pyy101
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