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GLYX-13, an NMDA receptor glycine site functional partial agonist enhances cognition and produces antidepressant effects without the psychotomimetic side effects of NMDA receptor antagonists

INTRODUCTION: The N-methyl-d-aspartate receptor-ionophore complex plays a key role in learning and memory and has efficacy in animals and humans with affective disorders. GLYX-13 is an N-methyl-d-aspartate receptor (NMDAR) glycine-site functional partial agonist and cognitive enhancer that also show...

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Dades bibliogràfiques
Publicat a:Expert Opin Investig Drugs
Autors principals: Moskal, Joseph R, Burch, Ronald, Burgdorf, Jeffrey S, Kroes, Roger A, Stanton, Patric K, Disterhoft, John F, Leander, J David
Format: Artigo
Idioma:Inglês
Publicat: 2013
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4721220/
https://ncbi.nlm.nih.gov/pubmed/24251380
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1517/13543784.2014.852536
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