GLYX-13, a NMDA Receptor Glycine-Site Functional Partial Agonist, Induces Antidepressant-Like Effects Without Ketamine-Like Side Effects

Recent human clinical studies with the NMDA receptor (NMDAR) antagonist ketamine have revealed profound and long-lasting antidepressant effects with rapid onset in several clinical trials, but antidepressant effects were preceded by dissociative side effects. Here we show that GLYX-13, a novel NMDAR...

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Detalhes bibliográficos
Main Authors: Burgdorf, Jeffrey, Zhang, Xiao-lei, Nicholson, Katherine L, Balster, Robert L, David Leander, J, Stanton, Patric K, Gross, Amanda L, Kroes, Roger A, Moskal, Joseph R
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2013
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3671991/
https://ncbi.nlm.nih.gov/pubmed/23303054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2012.246
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