A NMDA receptor glycine site partial agonist, GLYX-13, that simultaneously enhances LTP and reduces LTD at Schaffer collateral-CA1 synapses in hippocampus

N-methyl-D-aspartate glutamate receptors (NMDAR) are a key route for Ca(2+) influx into neurons important to both activity-dependent synaptic plasticity and, when uncontrolled, triggering events that cause neuronal degeneration and death. Among regulatory binding sites on the NMDAR complex is a glyc...

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Hlavní autoři: Zhang, Xiao-lei, Sullivan, John A., Moskal, Joseph R., Stanton, Patric K.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2008
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2661239/
https://ncbi.nlm.nih.gov/pubmed/18796308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2008.08.018
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